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Xanthine Oxidase Substrate Drugs: Febuxostat is an XO inhibitor. Drug interaction studies of Febuxostat with drugs that are metabolized by XO (e.g., theophylline, mercaptopurine, azathioprine) have not been conducted. Inhibition of XO by Febuxostat may cause increased plasma concentrations of these drugs leading to toxicity. Febuxostat is contraindicated in patients being treated with azathioprine, mercaptopurine, or theophylline.
Cytotoxic Chemotherapy Drugs: Drug interaction studies of Febuxostat with cytotoxic chemotherapy have not been conducted. No data are available regarding the safety of Febuxostat during cytotoxic chemotherapy.
In Vivo Drug Interaction Studies: Based on drug interaction studies in healthy subjects, Febuxostat does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine. Therefore, Febuxostat may be used concomitantly with these medications.
